Peptide Active Data Details
Basic Peptide Information
DICL ID
DICL_Pep_02035
Ion Channel
Neuronal acetylcholine receptor subunit alpha-6/alpha-3/beta-2/beta-3
Peptide Function
Antagonist
Gene Name
CHRNA6/CHRNB2/CHRNA3/CHRNB3
Activity Data (nM)
IC50
450 nM
Ki
Not available
EC50
Not available
Kd
Not available
Biologically Active
Not specified
Sequence Information
Peptide Sequence
TCRSSGRYCRSPYDRRRRYCRRITDACV
Peptide UniProt Accession
UniParc
UPI00085DE742
Peptide Synonyms/Alias
[CHEMBL4553407; GeXIVA[1;4]; GLXC-27609; BDBM50520487; TC(1)RSSGRYC(2)RSPYDRRRRYC(2)RRITDAC(1)V; Thr-Cys(1)-Arg-Ser-Ser-Gly-Arg-Tyr-Cys(2)-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Cys(2)-Arg-Arg-Ile-Thr-Asp-Ala-Cys(1)-Val]
Peptide Species
Conus generalis (General cone)
Peptide Name
Alpha-conotoxin GeXIVA
CAS Number
Not available
Experimental Conditions
pH
pH 7.1 to 7.5
Holding Potential (mV)
−70 mV
Temperature
Not mention
Test Method
Patch-clamping
Test Species
Xenopus laevis oocyte
Binding Information
Binding Site
Not specified
Binding Site Residue
Not specified
Ion Channel Information
Gene Abbreviation (ABB)
nAChRs
Ion Channel UniProt Accession
Source Organism
Homo sapiens (Human)
References & Disease Information
Disease
Not specified
PubChem CID
Not available
URL
Not available
PMID
Patent
Not available